遗传学团队
Sittideth Sangnual先生
- 遗传实验室首席执行官
教育背景
- 2010-2013年，玛希敦大学诗里叻医院医学院理学硕士（免疫学）。
- 2006-2010年，东方大学科学系理学学士（微生物学），一等荣誉（金奖）。
工作经验
2018年6月至今，Inspire IVF诊所（曼谷）遗传实验室负责人。
- 为植入前遗传学检测（PGT）设置遗传实验室并进行PGT，包括SNP和Karyomapping（Illumina）（>200个PGT周期，>1,000个胚胎）。
- 审核、分析患者报告。
- 执行和编制SOP文件（指导组织正确和一致操作的文件，明确操作步骤，并可根据各部门和组织的适当性进行改进，以实现可操作的结果，包括管理实验室设备、化学品和试剂的控制）
2015年5月至2018年5月，在STORK A.R.T.（曼谷）担任遗传技术员。
- 使用NGS、SNP和Karyomapping技术进行PGT检测（>1,000个周期，>4,500个胚胎）
- 数据分析、报告和实验室设备、化学品和试剂库存管理。
2014年1月至2015年4月，诗里叻医院（分子医学处）研究助理（分子生物学）。
- 使用全基因组关联研究和外显子组测序技术检测导致肾结石和DRTA（远端肾小管酸中毒）疾病的基因。
- 通过RT-PCR和HRM分析筛查患者基因突变
Honors, Presentations, and Workshops
1
Gold Medalist of Microbiology Major (the highest-ranking undergraduate), 2010
2
Excellent Science Student Award, Professor Dr. Tab Nilanidhi Foundation for graduates in science nationwide, 2010
3
Sangnual S, Rungroj N, Nettuwakul C, Sawasdee N, Sritippayawan S, Chuawattana D, Yenchitsomanus P. High Resolution Melting Analysis for Detection of SCN10A Gene Mutation in Northeastern Thai Patients with Nephrolithiasis. International Conference in Medicine and Public Health (ICMPH2013), 24-28th June 2013, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok. (3rd prize of oral presentation)
4
Sangnual S, Rungroj N, Nettuwakul C, Sawasdee N, Sritippayawan S, Chuawattana D, Yenchitsomanus P. Analysis of SCN10A gene mutation in Northeastern Thai patients with nephrolithiasis by high resolution melting method. 18th National Genetics Conference 2013 (NGC2013) “Genetics towards ASEAN”, 17-19th July 2013, Ambassador Hotel, Bangkok. (Best prize of oral presentation
5
Attended “Reproductive and Genetic Health Workshop” held at Mandarin Oriental, Bangkok (2015) organized by illumina
6
Attended “Reproductive and Genetic Health Symposium” held at Le Meridian Hotel, Bangkok (2016) organized by illumina
7
Attended training program “NGS and SNP array for PGT testing” held at Shanghai, China (2017) organized by Unimed Biotech (Shanghai) Co., Ltd.
Publications
1
Sangnual S, Rungroj N, Nettuwakul C, Sawasdee N, Sritippayawan S, Chuawattana D, Yenchitsomanus P. Analysis of SCN10A gene mutation in Northeastern Thai patients with nephrolithiasis by high resolution melting method. Thai J Genet 2013; S(1):87-90.
2
Nettuwakul C, Praditsap O, Sawasdee N, Rungroj N, Ruamyod K, Watanapa WB, Junking M, Sangnual S, Sritippayawan S, Cheunsuchon B, Chuawattana D, Rojsatapong S,Chaowagul W, Dib-Hajj SD, Waxman SG, Yenchitsomanus PT. Loss-of-function mutations of SCN10A encoding NaV1.8 α subunit of voltage-gated sodium channel in patients with human kidney stone disease. Sci Rep. 2018 Jul 11;8(1):10453.
3
Rungroj N, Nettuwakul C, Sawasdee N, Sangnual S, Deejai N, Misgar RA, Pasena A, Khositseth S, Kirdpon S, Sritippayawan S, Vasuvattakul S, Yenchitsomanus PT. Distal renal tubular acidosis caused by tryptophan-aspartate repeat domain 72 (WDR72) mutations. Clin Genet. 2018 Nov;94(5):409-418.