Embryo biopsy is select cells from the embryo to screen for genetic disease of each embryo in the 5th or 6th day blastocyst embryo stage. This stage of embryo has a layer of tissue cells 2 types areTrophectoderm (TE), which will develop as part of the wall that covers the embryoand placenta. Detection chromosome abnormal can be checked by extraction of one cell while the embryo is growth in 3 days with appropriate methods such as
Laser method is used to penetrate the embryonic cell wall to extract the cells. It will not affectdevelopment of the embryo in any way. The embryo was not detected as abnormal will be selected for implantation back into the uterus. An embryo biopsy is done by Embryologistin a laboratory using a special technique. The embryo DNA can be examined “by PGT”.
Difference between PGT-M and PGT-A
The difference isselection cells from embryonic tissue to screen for abnormal in parents without hereditary disease.To investigate common chromosomal abnormalities in the general population. This can know quantity of chromosomes in the embryo and also know the sexual chromosomes.If there have increase or decrease in the quantity of chromosomes in the embryo which is abnormal and is not suitable to be implanted in the uterus. It is primarily, we will test for chromosome abnormal that may cause a genetic disease or a defect in the body, such as the chromosome that develops causing Down’s syndrome.
PGT-M method ismethod detection specific abnormal chromosome,because it can detect 240abnormalities genes and can help spouses get a healthy child. Although both parents may be carriers of hereditary disease, PGT-M method detection can diagnose genetic disorders specific to certain diseases before the embryo is transferred into the uterus. This is important in reducing the risk of developing infant abnormalities in those who parents have genetic diseases such as thalassemia. Red blood cell disease, Cystic fibrosis diseaseincluding other diseases.
In most cases, this is recommended in couples with who one or both of them have been diagnosed with a carrier or hereditary disease or already had a child with a genetic disease. In this way we can select healthy and non-geneticdisease embryos and able to know the sex of that embryo.
Customer who suitable for diagnosis PGT
Many couples who choose diagnosis abnormal chromosome.However, a spouse who a doctor will consider diagnosis PGTmethod, The characteristics of inspector are as follows:
- Women over 35 years old because they have a higher chance of developing chromosomal abnormalities and other complications.
- Have a family history of genetic disorders.
- People who have had a history of infertility treatment with multiple IVF but have not been successful.
- People who have had a history of multiple miscarriages.
Human eggscell often have abnormal chromosomes and will have a higher percentage when the female gender ages increase. In general, approximately 30-60% of embryos will experience some type of chromosomal abnormality which increased significantly with the age of the female. As shown in the chart below.